ABSTRACT
COVID-19 has a risk of thrombotic complications. Serotonin plays an important role in pathogenesis of thrombosis. Purpose. To evaluate level of serotonin and its metabolite in the blood of children with COVID-19. Methods. This study included 72 children aged 3 to 17 years. Of these, 43 patients (mean age 11.2 +/- 4.8 years) diagnosed with COVID-19 without comorbidities made up the study group, 29 healthy children (mean age 11.8 +/- 3.8 years) - the control group. Concentration of serotonin and its metabolite (5-HIAA) in the blood was determined using high performance liquid chromatography with electrochemical detection. Computed tomography data were used to determine severity of lung damage. Results. In our study children with COVID-19 aged 3 to 17 years had significantly higher serotonin and its metabolite levels compared to the control group. Concentration of serotonin in plasma in main group was 20-30 times higher than in the same-age control. The 5-HIAA/serotonin ratio in children with COVID-19 is significantly lower than in the control group. Levels of serotonin and 5-HIAA in children with COVID-19 depending on the severity of CT-scan lung damage showed no significant differences. Conclusion. Serotonin and its metabolite levels in plasma of children with COVID-19 is significantly increased. It may be related to platelet hyperactivation in SARS-CoV-2 infection and increased risk of thrombosis, which requires further research. Copyright © 2022 National Academy of Pediatric Science and Innovation. All rights reserved.
ABSTRACT
Multisystem inflammatory syndrome in children associated with COVID-19 is a new disease, information first appeared in April 2020. There were reported cases of hospitalized children with unusual symptoms, manifested primarily by fever and multisystem inflammation from the pediatricians in the UK and other countries during the coronavirus infection pandemic (COVID-19). Some of these children were in critical condition with symptoms of shock and multiple organ failure, and some children had manifestations similar to Kawasaki disease. Despite the fact that COVID-19 in children is relatively easy, some of the «convalescents» after 2-6 weeks develop symptoms largely identical to the manifestations of severe forms of new coronavirus infection in adults. The report presents own clinical cases of multisystem inflammatory syndrome that developed in children after acute form of a new coronavirus infection. The authors discuss the possible clinical variants of the syndrome, its origin and outcomes. © 2021 National Academy of Pediatric Science and Innovation. All rights reserved.
ABSTRACT
Objective. To describe clinical and laboratory features of COVID-19 in children admitted to the hospital. Children characteristics and research methods. The authors carried out a retrospective observational study, which included 204 children admitted to the Kazan hospital with a diagnosis of “new coronavirus infection” in the period from May 1 to October 30, 2020. Results. It was revealed that all hospitalized children had RNA of the SARS-CoV-2 virus (100%) in a smear from the nasopharynx and oropharynx detected by PCR and only 50% of patients were diagnosed with lung tissue lesions by computed tomography. The clinical picture of COVID-19 in children most often corresponds to the classic manifestations of a respiratory viral infection. Risk factors for the development of severe forms, described in adults, were recorded only in isolated cases in our study. Conclusion. The clinical picture of COVID-19 in children most often corresponds to the classic manifestations of a respiratory viral infection. Risk factors for the development of severe forms, described in adults, were recorded in isolated cases in our study. © 2021 National Academy of Pediatric Science and Innovation. All rights reserved.
ABSTRACT
Currently, the researchers from various countries have demonstrated that COVID-19 in children is diagnosed less frequently, and the course and severity of the pathological process is less pronounced than in adults. Children with COVID-19 often have asymptomatic and mild forms. However, the risk of developing severe course of COVID-19 is typical for children from risk groups. Newborns and young children, congenital malformations and concomitant diseases, primarily accompanied by immunodeficiency states of various etiologies (oncological and autoimmune diseases, diabetes mellitus) are the risk factors for the development of severe forms of coronavirus infection. The article presents two clinical cases of COVID-19 in children with acute lymphoblastic leukemia. It is shown that children with concomitant oncohematological pathology often have both mild and severe forms of coronavirus infection.